[5][6] This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family.

EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system.

Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats.

The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis.