A new nurse manager causes friction among the staff, following a successful operation Weaver no longer needs her cane, Pratt journeys to Africa where he joins Carter on a relief mission while a face from Sam's past leaves the lives of Abby and Kovač hanging in the balance.

It is a bad day for Kovač as he and Sam can not be civil after their disruptive break up, and a new nurse manager, Eve Peyton, enforces her strict and efficient new procedures.

In the wake of Lewis' sudden departure, new attending physician Victor Clemente arrives to help make the ER more efficient, but the residents are not too fond of him, despite his wide-ranging knowledge.

The treatment options for a 10-year-old victim of a shooting- who has already been abducted and sexually abused for months- sparks a furious argument between Kovač and Clemente, which Abby becomes stuck in the middle of.

Pratt and Weaver try to make a Christmas miracle happen for a young girl whose life hangs in the balance after two gang members randomly shoot her.

Haleh holds her annual choir tryouts, Eve crosses the line with a disruptive patient and pays for it, Clemente gets a visit from Jodie (Callie Thorne), a past lover.

Anspaugh and Weaver discuss liabilities arising from Clemente's erratic behaviour, including whether Kovač is doing an adequate job as Chief in the ER.