In the finals, Cloud9 defeated SK Gaming 2–1 to become the ESL Pro League Season 4 Champions and take home $200,000 prize money; this upset would also mark the first time a North American won an international premier event since iBUYPOWER won ESEA Season 16 - Global Invite Division in 2014.
Teams within each continent played each other twice to determine the top four qualifiers to the Finals in Brazil.
Teams that placed seventh to eleventh are automatically invited to next season's ESL Pro League.
The top team in each group received a bye and automatically moved onto the Semifinals.
For instance, Skyler "Relyks" Weaver left eUnited in the middle of the season and was replaced with Jacob "kaboose" McDonald.
For instance, Timothée "DEVIL" Démolon was replaced with Christophe "SIXER" Xia on Team EnVyUS midway through the season.
However, FaZe Clan acquired the Danish in-game leader before the São Paulo Finals.
1Team Liquid takes Renegades's spot in the EPL Finals due to Renegades opting out of the trip to Brazil and instead headed to play in the ELEAGUE Major 2017 Asia Minor in Johor Bahru, Malaysia.