He is currently a Professorial Lecturer and Distinguished Diplomat in Residence at American University's School of International Service where he teaches courses related to diplomacy and US foreign policy.

He was an adviser for HSBC Latin America on improving management of financial crime risk from 2015 until 2019 and served on the board of the American Foreign Service Association from 2017 to 2019.

[5] A career diplomat starting in 1975, Wayne first served as a China analyst in the Department of State and was then posted overseas as a political officer in Rabat, Morocco.

He was named First Secretary at the U.S. Embassy in Paris heading a section following French politics and working to promote US-French anti-terrorism cooperation (1984–87) following a mid-career Masters of Public Administration at Harvard University's John F. Kennedy School of Government (1983–84).

[5] His appointment as Principal Deputy Assistant Secretary in the Bureau of European Affairs in 1997 gave Wayne broader responsibilities including in the management of U.S. relations with the European Union, the OECD, the G-8, regional economic and global topics, and Nazi restitution issues, as well as oversight of bureau management and public diplomacy programs, including the overseeing integration of the first office of the US Information Agency (USIA) into the State Department.

He played an important role in organizing the Stability Pact Summit for South West Europe in 1999, for which he subsequently received a Presidential Distinguished Service Award.

He played a leading role in building international cooperation against the financing of terrorism following the attacks of September 11, 2001 and in coordinating a number of reconstruction and assistance donor conferences during this time including those for Afghanistan, Iraq, the countries affected by the 2004 Indian Ocean Tsunami, and the 2005 Pakistan earthquake.

In June 2009, Ambassador Wayne was asked to serve in a newly created position as Coordinating Director for Development and Economic Affairs in Kabul, Afghanistan, as part of the US civilian surge into that country.

In 2014, the number of Mexicans studying in the U.S. doubled to over 30,000 and some 50 new university level partnerships were established, thanks to cooperation under the Bilateral Forum on Higher Education.

Mission Mexico's outreach also grew massively during Wayne's tenure, for example, reaching 1 million Facebook likes for the Embassy alone by September, 2015.

[10] In October 2015, Wayne was chosen to receive the State Department's Charles E. Cobb Jr. Award for Initiative and Success in Trade Development.