Earl Andrew Hamilton (July 19, 1891 – November 17, 1968) was an American left-handed pitcher for the St. Louis Browns (1911–16, later in 1916–17), Detroit Tigers (1916), Pittsburgh Pirates (1918–23), and the Philadelphia Phillies (1924) of Major League Baseball (MLB).

Born in Gibson City, Illinois, Hamilton played his first major league game on April 14, 1911.

Along with Wilbur Cooper, Whitey Glazner, and Babe Adams, he helped make up a good rotation for Pittsburgh, culminating with a second-place finish in 1921 (behind only the New York Giants, 4 games).

He also made the top 10 in losses three times (1914, 15, 21), and ended up finishing only two years of his career with a winning record; his 6–0 season of 1918 and 1922 (11–7).

Hamilton pitched 16 shutout innings on July 16, 1920, with the Pirates, before losing 7–0 against the New York Giants, clearly having run out of gas in the 17th.