He had no surviving male issue, so the Marquessate and his other non-inherited titles became extinct on his death in 1491, whilst the barony passed de jure to his younger brother Maurice.
However, William had disinherited Maurice because he considered him to have brought shame on the noble House of Berkeley by marrying beneath his status to Isabel, daughter of Philip Mead of Wraxhall, an Alderman and Mayor of Bristol.
Thus on the death of King Edward VI in 1553, Henry VII's unmarried grandson, the Berkeley inheritance returned to the family.
Roger I "de Berkeley" held extensive lands in-chief of the king in 1086, as recorded by Domesday Book, including Dursley and retired as a monk to St Peter's Abbey, Gloucester in about 1091.
In 1152 Roger III was deprived of the farm of Berkeley during the civil war between King Stephen and the Empress Maud.
To mollify the ill feelings of Roger of Dursley, Henry II encouraged each family to marry their respective male heirs to the eldest daughters of the other, which was successfully accomplished.