East 233rd Street begins at an interchange with Jerome Avenue and Interstate 87, the Major Deegan Expressway, in Van Cortlandt Park.

One block east at Carpenter Avenue, the road passes by Our Lady of Mercy Medical Center on the south side.

In the neighborhood of Eastchester, the road passes by the second subway station, which serves the 5 train.

[2] Between Webster and Provost Avenues, East 233rd Street was once part of NY 22, which previously continued into Manhattan.

[5] There are two New York City Subway stations along East 233rd Street: There is access to the following buses provided by the Metropolitan Transportation Authority on East 233rd Street: The entire route is in the New York City borough of the Bronx.