The club were founded in 2003 as Carlisle Centurions by former international Bev Risman and joined the North West Division of the Rugby League Conference which it won.
The Centurions went on to reach the Grand Final of the Harry Jepson Trophy in 2003 when they were narrowly beaten at Wilderspool Stadium by Bridgend Blue Bulls.
The club was reformed in 2006 under coach Geoff Grieves and returned to the Rugby League Conference in 2006 joining the North Division.
The club began to cut its early reliance on out-of-season West Cumbrian British Amateur Rugby League Association players and focused on gaining new recruits.
Carlisle Centurions withdrew from the National Division mid-season in 2010 after suffering a string of heavy defeats and struggling to raise a team.