The East Des Moines Industrial Historic District is a nationally recognized historic district located in the East Village of Des Moines, Iowa, United States, directly east of the Downtown Des Moines area.

[3] It also includes the Northwestern Hotel, which was individually listed on the National Register of Historic Places (NRHP).

It is a rare-surviving group of manufacturing, warehousing, and railroad-related properties in the city.

[3] The contributing structures include two railroad bridges and a pump house and the contributing sites are the locations of extant or former railroad rail bed and rail siding segments.

The district's "buildings, structures, and sites that show variety in architectural appearance, materials, and technological progression reflective of the period of significance.