East Kilbride, Strathaven and Lesmahagow was a county constituency of the House of Commons of the Parliament of the United Kingdom, which was first used in the general election of 2005.

Further to the completion of the 2023 Periodic Review of Westminster constituencies, the seat was subject to boundary changes which included the loss of Lesmahagow.

[1] As created by the Fifth Review of the Boundary Commission for Scotland, the constituency covered part of the South Lanarkshire council area.

However, the constituency also included the settlements of Auldhouse, Blackwood, Caldermill, Chapelton, Drumclog, Glassford, Kirkmuirhill, Jackton, Nerston, Stonehouse and Thorntonhall.

Following the defection of sitting MP Lisa Cameron in October 2023 from the SNP, the constituency was represented by the Conservative Party for the first time.