[2] As the society's recording secretary, Ramsey acquired a collection of papers and correspondence from early Tennesseans such as William Blount, John Sevier, Samuel Wear, Alexander Outlaw, and James Hubbert.

[3] The society began admitting women and hosted lectures on Fort Loudoun, Irish nationalist John Mitchel, and the state of Franklin, and featured speaker Fitzhugh Lee.

The society began publishing its annual scholarly journal in 1929 and hosted lectures by historians Stanley J. Folmsbee and Samuel Cole Williams.

[2] In 1946, the society published a comprehensive history of Knox County, The French Broad-Holston Country, as part of the state's sequicentennial celebrations.

The book, edited by Rothrock, included a history of the county written by Folmsbee with contributions by Harvey Broome.

MacArthur's history was republished in the 1982 book, Knoxville: Crossroads of the New South, which included photographs from the McClung Collection.

Displays include items owned by Davy Crockett and John Sevier, memorabilia from the Appalachian Expositions of 1910 and 1911, artifacts from the Battle of Fort Sanders, a complete trolley car, a drugstore display, and early country music instruments and memorabilia.

The center displays works by regional artists such as Lloyd Branson, Adelia Armstrong Lutz, Catherine Wiley, and Joseph Knaffl.