Eastern Air Lines Flight 375, registration N5533,[1] was a Lockheed L-188 Electra aircraft that crashed on takeoff from Logan International Airport in Boston, Massachusetts, on October 4, 1960.

The plane and crew turned around in Boston as Flight 375, which was scheduled to travel to Philadelphia, Pennsylvania; Charlotte, North Carolina; and Atlanta, Georgia.

The fuselage broke into two pieces; eight passengers and two flight attendants in the rear section were thrown out of their seats and were quickly picked up by boats already in the bay.

A Navy Reserve commander who arrived at the scene of the accident shortly afterwards stated many passengers were stuck in their seats and unable to get out before sinking into the bay.

During civil litigation by the family of a deceased passenger, it was discovered that the airplane's maintenance records showed that the adjustable seat had accidentally slid backward during a takeoff about six weeks prior to Flight 375.

Expert testimony during the trial claimed that the co-pilot of Flight 375 (who during an emergency would typically be flying the plane while the pilot attempts to locate and solve the problem) most likely pushed the rudder pedal to compensate for unexpected yaw.