The railway line runs between Ludhiana in Punjab and Dankuni (near Kolkata) in West Bengal via Meerut and Kanpur in Uttar Pradesh.

This will pass through the important districts of Sahnewal, Doraha, Ludhiana, Sirhind, Rajpura, Ambala, Yamunanagar, Saharanpur, Muzaffarnagar, Meerut (Logistic Hub), Hapur, Bulandshahr, Aligarh, Hathras, Barhan, Tundla, Firozabad, Etawah, Kanpur, Prayagraj and Chandauli.

The proposed junctions on this line are Dhandharikalan, Sirhind, Rajpura, Khalanaur, Khurja, Daudkhan, Tundla, Bhaupur, Prempur, Manauri, Karchhana, Jeonathpur, Mughalsarai Junction railway station, Ganjkhwaja, Sasaram, Dehri On Sone, Son Nagar, Gomoh, Andal, Bardhaman and Dankuni (The eastern terminal point).

Ashok Agarwal, national president, Indian Industries Association (IIA), said "We have also received queries related to the allotment of land along the Ganga Expressway from investors.

[5][6] Built by Alstom at Prayagraj, OCC will house command and control center to monitor all trains and power supply systems on Eastern Dedicated Freight Corridor.