[3] The nonvenomous, colubrid snake is indigenous to eastern and central North America.

[4] It was once thought by herpetologists to intergrade with the scarlet kingsnake (Lampropeltis elapsoides) in a portion of its southern range, but this has been disproved.

[10] The eastern milk snake is a species commonly found in rural areas where hibernation and feeding sites, such as buildings and mammal burrows, are abundant, and it also uses a variety of open habitats and forest edges.

[11] Milksnakes in fragmented habitat, select locations with a greater number of cover objects within open patches surrounded by high density vegetation.

[12] The eastern milk snake is oviparous with an average clutch size of 4-12 eggs.

The eastern milk snake takes 3-4 years to reach full maturity.

[18] In a study on eastern milk snakes in Kansas, specific prey items were identified.

Common predators of the eastern milk snake include opossums, skunks, raccoons, hawks, owls, and coyotes.