He began his career as a répétiteur and conductor in Mainz, Darmstadt, Düsseldorf and Lübeck before being appointed General Music Director in Ulm in 1980.
He has been resident in Berlin since 1998, concentrating on extra-institutional work as a freelance conductor, project initiator and composer.
In 1999 he founded musikakzente 21 with the aim of developing cultural and music concepts for the twenty-first century, creating models of media networking and designing and realising implementation strategies.
In 2018 Kloke transcribed Wagner's Tristan und Isolde in a version for soli, chorus (ad lib.)
October 2010 through to March 2013: a series of performances of the new version of Act 3 of Alban Berg's opera Lulu was staged in Copenhagen, Oslo, Erfurt, Augsbutg, Dresden (Semperoper), Cardiff, Birmingham and Bozen.