In 2006 he toured the UK, recording a DVD in Leeds entitled Pedantic and Whimsical, which was largely a "greatest hits" set of his material to date.

[5] He has since garnered a raft of major broadcast credits, including five U.S. appearances on Late Night with Conan O'Brien (NBC).

He recorded a live DVD Different Class at the King's Theatre, Glasgow, on 23 March 2009, which was released on 23 November of that year.

Best Unseen Ads and Just for Laughs, and is a regular guest on The Panel, HeadJam, Mock the Week and Never Mind the Buzzcocks.

He has also appeared on Lily Savage's Blankety Blank,[7] Have I Got News for You, The Bubble, The Unbelievable Truth, Bring Me the Head of Light Entertainment and We Need Answers.

[8] Byrne featured in a series of comedy shorts on the MSN Video Channel[9] in which he discusses some of his pet hates, including occasional smokers and his girlfriend's snoring.

[13] In January 2013 Byrne was a contestant on episode 4 of BBC's The Great Comic Relief Bake Off and won the Technical Challenge with his lemon meringue pie.

[16][17] Describing his signature dish, smoked pork ribs, Byrne said, "I cover them in a dry rub that I've been perfecting by trial and error for years, then shove them in a barrel smoker for about 10 hours, spraying them with apple juice and cider to keep them moist.

[20][21] Byrne played the title character in the 2000 ITV adaptation of the pantomime Aladdin and had a small part in the 2000 comedy film Rat.

[22] Byrne plays the part of Irish radio presenter Dylan Dale in the British feature film version of Tony Hawks' book Round Ireland with a Fridge which was released in September 2010 and on DVD on 8 November 2010.

Since 2011, Byrne has written a column for the hillwalking magazine TGO in which he tries a different outdoor activity each month in the company of an expert.

[25] On 12 February 2022, Byrne announced via his Twitter account that his younger brother Paul had died aged 44 years old.