Edward Augustine "Fred" Knouff (June 1867 – September 14, 1900) was an American Major League Baseball pitcher from 1885 to 1889.

He played for the Philadelphia Athletics, Baltimore Orioles, St. Louis Browns, and Cleveland Blues.

Knouff started his professional baseball career in 1884, at the age of seventeen, with Newark of the Eastern League.

[1] In 1897, Knouff was serving as a Philadelphia firefighter when he fell and broke his back.

Doctors were unable to help him, and Knouff remained in a hospital until his death in 1900.