Edwin C. Kubale (November 22, 1899 – February 4, 1971) was an American football player and coach.

He served as the head football coach at Centre College in Danville, Kentucky from 1928 to 1937 and Southwestern Presbyterian University—now known as Rhodes College—in Memphis, Tennessee from 1938 to 1941, compiling a career college football coaching record of 69–55–8.

Kubale came to Centre College from Fort Smith, Arkansas, where he played for coach Frank Bridges.

He replaced All-American Red Weaver at the center position in 1921, the same year that Centre upset Harvard 6 to 0.

Kubale coached in the National Football League (NFL) during the 1944 season for the Brooklyn Tigers.