Edward J. Matesic (November 6, 1907 – June 4, 1988) was an American professional football player for the Philadelphia Eagles and the Pittsburgh Pirates.

Led the University of Pittsburgh in interceptions in 1931.

In 1931 only the statistics of yards and touchdowns were recorded and not the number of interceptions.

Was the Pittsburgh Pirates starting quarterback in 1936.

This biographical article relating to an American football quarterback born in the 1900s is a stub.