[4] On The Guiding Light soap opera, Prentiss played Ned (a "neglected youth") and was the program's "omniscient host.

"[5] Beginning in 1943, Prentiss was narrator for an hour-long block consisting of three soap operas: Today's Children, The Guiding Light and Woman in White.

An ad for the 15-minute program described it as follows: "Ed Prentiss, America's greatest story teller ... offers true and unusual tales, each with a surprisingly different ending.

"[9] He also was a regular on Arnold Grimm's Daughter,[10] Painted Dreams, Bud Barton,[11] The Romance of Helen Trent, Springtime and Harvest[12] and Holland Housewarming.

In 1957 Prentiss appeared as Bob Gentry on the TV western Cheyenne in the episode titled "Top Hand.