Edward Wayne Spiezio (born October 31, 1941) is an American former professional baseball third baseman.

He played in Major League Baseball (MLB) from 1964 to 1972 for the St. Louis Cardinals, San Diego Padres and Chicago White Sox.

This took place on April 8, 1969, in the bottom of the fifth inning against Houston Astros right-hander Don Wilson.

Spiezio also played for four different minor-league teams in parts of five seasons spanning 1963–1972, posting a .263 average with 47 homers and 191 RBI in 383 games.

He also played for the Leones del Caracas and Tiburones de La Guaira clubs of the Venezuelan Winter League.