Subitzky is a member of the Screen Actors Guild-American Federation of Television and Radio Artists, and the Writers Guild of America.

He was greatly influenced by the work of Harvey Kurtzman and to a lesser extent that of Will Elder, both of whom he met briefly in Mount Vernon when he was about 12 years old.

His connection with National Lampoon magazine was first established in 1972, when contributing editor Michel Choquette visited the School of Visual Arts cartooning class which Subitzky attended.

Subitzky subsequently became a long-term contributing editor; one or more of his comic strips, cartoons, and written articles appeared in almost every issue of the magazine.

Shary Flenniken, in the biography on her official website, describes Subitzky as "hysterically funny and unassuming".

His approximately 100 articles and written pieces for National Lampoon included “How I Spent My Summer” in the Self-Indulgence issue (December 1973, Vol.

[9] Two of the many fumetti, also known as photo funnies, that Subitzky wrote were "The Perfect Date" and "Every Red-Blooded American Boy's Dream: Three Pretty Girls Doing Just What You Want So You Can Masturbate!"

The Someday Funnies included pieces by William Burroughs, Federico Fellini, Tom Wolfe, Frank Zappa, and 165 others.

Subitzky voiced the part of the science-nerd hero, Timmy Johnson, who by clever control of the supply of deodorants, manages to save the world from alien invaders disguised as beautiful and seductive women.

In 1980, Subitzky wrote numerous pieces for a nationally syndicated series of five-minute horror stories, which were broadcast on radio.

[10] Subitzky conceived and wrote two National Lampoon albums: In 1980, Subitzky was hired as a comedy writer on The David Letterman Show (the morning show), where he helped create "The Imposter," a series of comedy sketches about a person who pretends to be celebrities in order to get on television.

[11] For the sketches, in most cases Subitzky wore his own clothes, and there was usually no attempt to make him look like the person he was purporting to be.

However, when he was claiming to be James Clavell, Subitzky wore a tuxedo, and when pretending to be Don Henley, he was dressed in a leather motorcycle jacket and a black sequined teeshirt.

When Subitzky was announced as being the viewer Elizabeth Callahan, he appeared in full drag and makeup, however, his real-life moustache was clearly visible.

More than 20 years after the piece was first published, it was still featured (both with and without its title, attribution, and introduction) on hundreds of websites, including versions translated into Dutch, French, German [7], Hungarian, and Spanish.

Subitzky has had a life-long interest in both science and philosophy, and he is especially fascinated by the very challenging "hard problem" of consciousness, i.e. why there is a subjective component to experience.

He also wrote the lyrics for a country song which appeared as background music in a bar scene in another film (Kandyland, 1987).

In 1977, he appeared on the cover of the book National Lampoon The Gentleman's Bathroom Companion as the Ty-D-Bol man (a spoof of commercials for a blue-tinted toilet bowl cleaner).

In the 1980s, Subitzky was the sole actor in a television commercial for a video game called Mountain King.

During the 1990s, Subitzky occasionally worked for the modeling agency FunnyFace Today, appearing in editorial images in a few publications, including Redbook.

A chapter about Subitzky (pages 208 – 213) forms part of the 2010 coffee-table book about the early years of National Lampoon magazine, Drunk Stoned Brilliant Dead: The Writers and Artists Who Made the National Lampoon Insanely Great by Rick Meyerowitz.

Brown, Gahan Wilson, and Ed Subitzky, I also knew about weird and rare and hilarious ways of changing one into the other.

[16] In June 2013, That's Not Funny, That's Sick: The National Lampoon and the Comedy Insurgents Who Captured the Mainstream, by Ellin Stein was published.

[18] Since 2015, Subitzky's drawing and writing has appeared in several issues of The American Bystander, a magazine which is edited and published by Michael Gerber, and the head writer of which is Brian McConnachie.

It is 184 pages long, paperback, and 9 x 12 inches in size, deliberately similar to the physical format of National Lampoon (Magazine).