Family friend and late Beatles guitarist, George Harrison, encouraged a seven year old Wynne to pick up the guitar.

He was involved with several bands whilst in school, including Bolshem People, which recorded in Wynne's studio attic in Rushmere, Wimbledon Common.

[2] After several line-up changes, Ozric Tentacles started to be guided more and more by Wynne, who aside from guitar and keyboards was also becoming responsible for beat programming and other studio efforts.

Wynne has also appeared as a guest musician in works by artists such as Jordan Rudess,[11] Amon Düül UK, Eat Static,[12][7] and Invisible System,[13] among others.

In 2007, he (along with ex-bandmate Merv Pepler) composed and programmed a track named "Sphere Wave's" for the Cognition Factor soundtrack.