He played as a running back in the National Football League (NFL) for nine seasons, primarily for the Houston / Tennessee Oilers / Titans franchise.

He attended Abington Senior High School until the tenth grade, and then transferred to Fork Union Military Academy.

Such choices are commonly made by high school football players hoping to improve their recruitment status with colleges, but for George, it meant another year of the rigorous military lifestyle.

Later in the game, with Ohio State leading by 2 points in the final quarter, George fumbled again, this time on Illinois' 1-yard line.

In the following season, George was listed in the depth chart as the team's third-string running back, behind Raymont Harris.

George was a first-round draft selection (14th overall pick) of the Houston Oilers (now the Tennessee Titans) in the 1996 NFL Draft, being selected after Jerome Bettis elected to be traded to the rival Pittsburgh Steelers over the Oilers when the St. Louis Rams replaced Bettis with Lawrence Phillips.

George is only the second NFL running back to rush for 10,000 yards while never missing a start, joining Jim Brown.

In 2001, George averaged just 2.98 per carry, the fourth lowest number in league history among running backs with more than 200 rushing attempts in a season.

He became the backup running back when Jones returned midway through the season, finishing with 432 yards on 132 carries and 4 touchdowns.

[13] In 2021, he became a semifinalist (of the 26-person Modern-Era list) for the Pro Football Hall of Fame, the first time he had made the stage since he was eligible.

On Saturday, April 28, 2007, George ran the Country Music Half Marathon (ending just outside then LP Field, now Nissan Stadium) in an unofficial time of 2:04:08.

[21] After he retired from football, George went back to complete his bachelor's degree in landscape architecture from Ohio State.

She is best known for being a part of the group SWV (Sisters with Voices) and later being a contestant on the 18th season of the CBS reality show Survivor.

George's jersey was retired by the Titans during a halftime ceremony against the Indianapolis Colts on September 15, 2019, along with former teammate Steve McNair who was killed in 2009.