During his stay in Chicago, Higgins also recorded a significant number of albums under his auspices and many more as a sideman with a wide variety of musicians, ranging in style from tenor saxophonists Hawkins to Sonny Stitt to Wayne Shorter; trumpeters Bobby Lewis to Harry Edison to Lee Morgan and Freddie Hubbard; and trombonists Jack Teagarden to Al Grey.

His versatility was captured on stage and records, backing up singers and leading his own projects as both pianist and orchestrator, working in every jazz circle from dixieland to modal styles.

Although he opted to decline the offer, Higgins was asked at one point by Art Blakey to join the seminal hard bop quintet, The Jazz Messengers.

During his career in East Asia, Higgins formed a successful trio with Joe Ascione (drums), and Jay Leonhart (bass).

Eddie Higgins's delicate tone and conception were often compared to those of Bill Evans, one of the most influential and successful jazz pianists.