Izzard's stand-up comedy tours have included Live at the Ambassadors (1993), Definite Article (1996), Glorious (1997), Dress to Kill (1998), Circle (2000), Stripped (2009), Force Majeure (2013) and Wunderbar (2022).

Izzard has also worked as a voice actor on films such as Five Children and It (2004), The Wild (2006), The Lego Batman Movie (2017) and the Netflix original series Green Eggs and Ham (2019).

Among various accolades, she won two Primetime Emmys for Dress to Kill and was nominated for a Tony Award for her Broadway performance in A Day in the Death of Joe Egg.

In 2022 and 2023, Izzard attempted to become the party's prospective parliamentary candidate (for Sheffield Central and Brighton Pavilion respectively); she was not selected in the members' ballots.

[8] Dorothy was a midwife and nurse, while Harold was an accountant who was working in Aden for British Petroleum at the time of Edward's birth.

[15][23][24] After splitting with Ballard, Izzard spent a great deal of the early 1980s working as a street performer in Europe and the United States.

[25] She then moved her act to the stand-up comedy venues of Britain, performing her routine for the first time at the Banana Cabaret in London's Balham area.

[12] She refined her comedy material throughout the 1980s and began earning recognition through improvisation in the early 1990s, in part at her own club, Raging Bull in Soho.

[30] In 1994, Izzard's West End drama debut as the lead in the world premiere of David Mamet's The Cryptogram with Lindsay Duncan, in the production at London's Comedy Theatre.

As part of an inside joke, she walked on stage with the five surviving Pythons and was summarily escorted off by Eric Idle and Michael Palin when attempting to participate in a discussion about how the group got together.

Izzard and Victoria Hamilton repeated their lead roles when the show was brought to Broadway in 2003 in the Roundabout Theatre Company production.

[34] Izzard has appeared in numerous films, starting with The Secret Agent in 1996, and has appeared as several real-life individuals, including Charlie Chaplin in The Cat's Meow, actor Gustav von Wangenheim in Shadow of the Vampire, General Erich Fellgiebel in Valkyrie and wartime pioneer of radar Robert Watson-Watt in the BBC drama film Castles in the Sky.

Her voice work has included the titular "It" in Five Children and It, Nigel in The Wild and the mouse warrior Reepicheep in The Chronicles of Narnia: Prince Caspian.

[39][40][41] Izzard appeared in the 2009 BBC science fiction miniseries The Day of the Triffids, based on the 1951 novel, alongside Jason Priestley, Vanessa Redgrave, Joely Richardson, Dougray Scott and Brian Cox.

[45] At the London 2012 Paralympic Games, Izzard presented the medals to the athletes who had won the 800m T54 race, including gold medalist David Weir.

[48] From 25 January to 3 March 2024, Izzard performed a one-person version of Shakespeare's Hamlet, adapted by her brother Mark and directed by Selina Cadell, at the Greenwich House Theater in New York.

[58] On 16 February 2016, the BBC announced that Izzard would attempt to run 27 marathons in 27 days through South Africa for Sport Relief.

[62] On 8 December 2020, Izzard announced[63] that she would attempt to run 31 marathons and perform 31 stand-up gigs, in the 31 days of January 2021 to raise money for a range of charities including Fareshare, Walking With The Wounded, Care International, United to Combat Neglected Tropical Diseases and Covenant House.

In May 2005, she appeared on the BBC's political debate show Question Time, describing herself as a "British-European", comparing this with other cultural identities such as "African-American".

[24] On a June 2017 episode of Real Time with Bill Maher, she claimed to be working in English, French, German and Spanish.

[88] On 5 December, it was reported that a local Sheffield City councillor had been selected as the party's candidate for the safe seat, with Izzard coming second in the members' vote.

[72] In August 2023, Izzard announced her campaign to become the Labour candidate for Brighton Pavilion at the next general election, following the decision of the incumbent Green MP Caroline Lucas not to recontest the seat.

[90] Izzard uses a stream-of-consciousness delivery that jumps between topics, saying in a 2004 interview with The Guardian that "it's the oral tradition [...] human beings have been doing it for thousands of years".

[96] In 2020, she requested she/her pronouns for an appearance on the TV show Portrait Artist of the Year and said she wants "to be based in girl mode from now on".

[98] In the past, Izzard identified as a transvestite and has also called herself "a lesbian trapped in a man's body"[99] and "a complete boy plus half girl".

During the 2008 Stripped tour, she said, "I was warming the material up in New York, where one night, literally on stage, I realised I didn't believe in God at all.

[110] In 2003, Izzard received an honorary Doctorate of Letters from the University of East Anglia, Norwich, for her work promoting "modern languages and tolerance of other cultures and lifestyles", and for having "transcended national barriers" with humour.