He was a starting defensive tackle for the champion Philadelphia Eagles in the 1960 NFL Championship Game and later their head coach in 1971 and 1972.

The bulk of his career was spent with the Philadelphia Eagles, where he was the starting defensive tackle for the 1960 World Championship team.

After his retirement from playing, Khayat began his twenty-five-year career in the National Football League as a coach.

In his next stop with the Philadelphia Eagles (1971–1972), he was named Head Coach three games (after Jerry Williams was fired) into the season and rallied the team to a 6-4-1 finish.

Three weeks later, after a loss to the St. Louis Cardinals meant that the Eagles finished last in the NFC East, Khayat was fired the next day.

They were one of only a few sets of brothers to play on the same team at the same time, and they are both members of the Mississippi Sports Hall of Fame.

Since its inception, the tournament, which was renamed in their honor in 2015, has raised hundreds of thousands of dollars for the benefit of the county's Special Olympics programs.