Edward Mills "Eddie" Machen (June 15, 1932 – August 8, 1972) was an American professional boxer.

He was highly rated and fought most of the big names of his era and he defeated many of the important names of his period such as Bob Baker, Jerry Quarry, Niño Valdés, Joey Maxim, Willi Besmanoff, Tommy Jackson, Brian London, Howard King and Doug Jones (boxer) Machen often fought at Civic Auditorium or the Cow Palace in San Francisco.

Later that year he met top contender and future champion, Sonny Liston, and although he lost by a clear 12-round unanimous decision, fought a sharp hit and move match that many believed was later studied by heavyweight champion Muhammad Ali.

In 1962, Machen had two more wins before he had a draw with high-ranked big hitter Cleveland Williams in Houston in July 1962.

But he closed that year with two wins, one particularly notable over future contender Jerry Quarry, which was Quarry's first defeat In late 1966, Machen fought young future heavyweight champion Joe Frazier and lost in a tenth-round technical knockout.

Machen retired in 1967 at age 35 following consecutive losses to Henry Clark, Boone Kirkman and Joe Frazier.

Eddie Machen was found dead in San Francisco on August 8, 1972, apparently the result of a fall from a second story apartment window.