Eddie Macon's Run is a 1983 American action thriller drama film written and directed by Jeff Kanew, based on the 1980 novel of the same name by James McLendon.

Eddie is a man that has relocated from Florida to Texas in order to better provide for his wife Chris and their young son Bobby, who suffers from a blood disorder.

His temper leads him into a few minor infractions that land him in jail, but after an unsuccessful escape attempt, he finds himself with an excessively harsh prison sentence in light of his original offences.

With no one pursuing him any longer, Eddie is able to meet his wife and son on a bridge over the Rio Grande and the three begin their journey to the border into Mexico for freedom.

In addition, three actors made their first film appearances, in minor roles: J. T. Walsh and Dann Florek are two guys in a bar, while John Goodman plays Mr. Hebert.