Like Dick Clark in the United States, Miró was known for his longevity in front of the cameras while aging relatively little-to-none physically.

During the long television run of El Show de las 12, he came into contact with many famous entertainers, both local and foreign.

His big break came in 1964 when the actor-turned-producer Paquito Cordero offered him a job as the host of the new upcoming television program El Show de las 12 at Telemundo Channel 2, which first broadcast in January 1965.

Its growing popularity prompted the character, whose name was later changed to "La Comay", to have its show on Telemundo titled Xclusivo, with Miró as the host.

Santarrosa intended to bring Eddie Miró with him to co-host the show, now renamed SuperXclusivo but Miro's was very loyal to Telemundo and Paquito Cordero, therefore rejecting the offer.

Miró married choreographer Juanita "Ita" Medina on August 28, 1965,[4] at the Los Angeles Church in Carolina, Puerto Rico.

[4] He refused to take time off work, keeping on his daily schedule of hosting El Show de las 12 even as he had cancer.