[2] Pepperell turned professional in 2011 but failed to earn a place on either the European or Challenge Tours, and he began 2012 playing on the mini-tours.

However he received an invitation to the Allianz Open Côtes d'Armor Bretagne in May, the fourth event on the Challenge Tour schedule.

On a very difficult final day in windy conditions, Pepperell shot a two-under 69, while all the other leaders were shooting over-par rounds, to come from seven strokes behind and join the playoff.

In February 2018, Pepperell broke through and won his maiden European Tour event at the Commercial Bank Qatar Masters by a single stroke over Oliver Fisher.

[5] On 14 October 2018, Pepperell shot 72 to go wire-to-wire and hold off the challenge of Alexander Björk and win his second European Tour title of the season at the Sky Sports British Masters at Walton Heath Golf Club.

[9] During 2020, Pepperell did a podcast alongside Andrew Cotter called The Pepper Pod, discussing golf matters and various other affairs.