Eddy De Lépine (born 30 March 1984 in Fort-de-France, Martinique) is a French sprinter.

Together with Ladji Doucouré, Ronald Pognon, and Lueyi Dovy, he won a gold medal in 4 x 100 metres relay at the 2005 World Championships in Athletics.

He finished 6th in the 200m at the 2006 European Athletics Championships in Gothenburg.

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