[6] Then, in July, he officially signed a five-year contract with the club, in a deal worth €500,000, and set a €45 million release clause.

In the 2015–16 season, Ederson started as a second choice in line for the first team, defended by compatriot and international Júlio César.

[11] Ederson's transfer equalled Axel Witsel's as the largest fee a club has ever paid for a Benfica player at the time.

He made his competitive debut for the club on 12 August 2017 in a 0–2 away win at Brighton & Hove Albion, where he kept a clean sheet.

[13] On 9 September against Liverpool, Ederson suffered a kick to the face by Sadio Mané, and was forced to leave the game after eight minutes of treatment.

[15] Ederson made his next start the following week in the Champions League against Feyenoord, sporting a piece of protective headgear.

[16] On 19 August 2018, Ederson became the first Manchester City goalkeeper to provide a Premier League assist, as his goal-kick was converted by Sergio Agüero for the opening goal in a 6–1 win over Huddersfield Town.

[20] Ederson was awarded the Golden Glove for keeping the most clean sheets (16) in the 2019–20 Premier League season after a 5–0 home win against Norwich City.

[25] Four months later, he was ruled out of the last game of the Premier League season and the 2024 FA Cup final after suffering a fractured eye socket in a collision with Cristian Romero in a win over Tottenham Hotspur.

[37] He was initially called up by Dorival Júnior for the 2024 Copa América, but was replaced before the tournament by Rafael after being unable to recover from a fractured eye socket.

[57] Regarded as a highly promising prospect in his formative years,[43] he stood out for his decision making, consistency, and composure in goal, as well as his ability to organise his defence, and has also become an intelligent reader of the game;[39][40][43][47] as such, some in the sport consider him to be one of the best goalkeepers in the Premier League and in world football.