[1] The Society hosts regular social and educational events in Edinburgh and has campaigned against the use of homeopathy and challenged claims of ghost sightings.

In the past the Society has also co-hosted special events, such as a talk by Marc Abrahams,[11] founder of the Ig Nobel Prizes and continues to work with various groups in the scientific and skeptical community.

Talks are also given by group members and cover a wide range of subjects including health care, science, atheism, the paranormal/supernatural, psychics, politics and psychology.

The group has covered both fiction and nonfiction genres, such as social psychology and biography, with books including When Prophecy Fails: A Social and Psychological Study of a Modern Group That Predicted the Destruction of the World by Leon Festinger, Henry Riecken, and Stanley Schachter, which contains one of the first published accounts of cognitive dissonance, and Bare-Faced Messiah: The True Story of L. Ron Hubbard by British journalist Russell Miller.

[18][19] As participants in this campaign, Edinburgh Skeptics organised a protest outside the Princes Street branch of Boots against its policy of selling homeopathic preparations as equivalent to mainstream scientifically based medicine.

[20] These 10:23 Campaign protests took place in 70 cities in 30 countries around the world[21] including Australia and New Zealand and resulted in no ill effects to those taking the products.

[22] Following the overdoses, Paul Bennett, professional standards director for Boots, responded by stating, "We know that many people believe in the benefits of complementary medicines and we aim to offer the products we know our customers want".

[27][28] When the public response to the consultation was announced, Liddle was quoted in the press stating that "Homeopathy is an unevidenced-based relic" and that "The Edinburgh Skeptics Society welcomes the consultation response and hopes that NHS Lothian acts appropriately in ending the funding of magic water on the NHS and using the money saved, [...] to fund more appropriate, evidence-based treatments and care".

Ash Pryce of Edinburgh Skeptics informed the press that the photograph "is a woman in a pink jacket coming down some stairs with a shopping bag" and not a ghost.

[30] The idea received a positive endorsement from celebrity sceptic Chris French, star of shows such as ITV's Haunted Homes, who believed the tour was the first of its kind in the UK.

[35] In 2013 members organised speakers for their events including Caroline Wilkinson, Professor of Craniofacial Identification at the University of Dundee,[36] and a presentation by Dr Stephen Makin entitled "Cock and Bull: Truth and Lies about Penis Size".

[41] In 2013 a lecture by Prof Alison Murdoch entitled "Ethical challenges in assisted reproduction" was sponsored by the Humanist Society Scotland.

The stall contains information leaflets and science demonstrations with public participation and touches on subjects such as alternative medicine, the paranorma and the existence of psychic abilities.

Members of the Society have been invited to give talks to other skeptics groups in the UK and Ireland on topics such as psychology, alternative medicine and the Burzynski Clinic.