She holds a PhD in History from the University of Maryland.

Edna Greene Medford served as Chair of the Department of History of Howard University for nearly eight years.

In July 2018, she became the Interim Dean of the College of Arts and Sciences of Howard University.

She compiled and wrote the introductions to the edited two-volume work The Price of Freedom: Slavery and the Civil War - Volume I , and The Price of Freedom: Slavery and the Civil War - Volume II , both published in 2000.

Edna Greene Medford was inducted as a Laureate of The Lincoln Academy of Illinois and awarded the Order of Lincoln (the State’s highest honor) by the Governor of Illinois in 2009 as a Bicentennial Laureate.