After previously competing in karting, Piscopo began his single seater career in Formula BMW USA in 2005, where despite missing the first rounds he finished fifth with three wins for EuroInternational.

In his debut season, he scored ten podiums finishing third in Formula Renault 2.0 Italia for Cram Competition, behind Dani Clos and teammate Adrian Zaugg.

[1] He joined A1 Team Italy to drive in the A1 Grand Prix series for the 2007–08 season, sharing duties with Enrico Toccacelo.

[1] He moved to the Italian Formula Three Championship in 2008, scoring seven wins on his way to second in the final standings, behind champion Mirko Bortolotti.

[2] He finished twelfth in the championship due to missing the final round to concentrate on his GP2 Asia campaign.