In 2009, Rombley hosted season one of the Dutch celebrity talent show Beste Zangers.

The career of Rombley started in 1995, with Gracia Gorré, Karima Lemghari and Susan Haps in the group called Dignity.

In 1996, Edsilia won the final of the Soundmixshow with a cover version of Oleta Adams' song, "I Just Had To Hear Your Voice".

This was the best result the Netherlands had achieved since their win in 1975 with Teach-In until The Common Linnets' second-place finish in 2014.

On 4 December 2019, she was announced one of the three presenters of the Eurovision Song Contest 2020 in Rotterdam, which was later cancelled due to the COVID-19 pandemic, alongside Chantal Janzen and Jan Smit.

[1][2] She later co-hosted Het Grote Songfestivalfeest (English: the Big Songfestival Party), a live concert show featuring artists from the past sixty-four years, at the Ziggo Dome in Amsterdam as a pre-event prior to the 2020 contest.

[3][4] In 2021 she was one of the four presenters of the Eurovision Song Contest 2021, together with Chantal Janzen, Jan Smit and Nikkie de Jager.

On 28 November Edsilia Rombley and Karin Bloemen sang during a benefit concert for Bangladesh, organised by Memisa, a foundation which works for the improvement of health care in developing countries.

Using one of the songs from the benefit concert in Bangladesh, her husband Tjeerd Oosterhuis created a version for a special cause.

In June 2006, Edsilia's single "Dan Ben Ik Van Jou" was released as an indication of an entirely new album with Dutch compositions.

In 2019, Rombley has been assigned to the role of Mary at The Passion, which is a Dutch television show which tells the Easter story in a musical way.