He served as Oberpräsident (governor) of the Grand Duchy of Posen (from 1830) and of the Saxony (from 1841), Westphalia (from 1846) and Brandenburg (from 1850) Provinces.

Flottwell was born in Insterburg in the Province of East Prussia (present-day Chernyakhovsk in Russian Kaliningrad Oblast), studied law at the University of Königsberg and entered the civil service at the Insterburg court in 1805.

[1] After the Napoleonic Wars he together with Oberpräsident Theodor von Schön re-organised the administration of the West Prussian province at Danzig.

When in 1830 the Polish November Uprising led by Michał Gedeon Radziwiłł broke out at Warsaw in Russian Congress Poland, his brother Antoni Radziwiłł was dismissed as Duke-Governor of the Prussian Grand Duchy of Posen by King Frederick William III and the sole rule passed to Flottwell as the new Oberpräsident.

He was a strong supporter of Germanisation and standardised schooling policies, which by some was seen as directed against ethnic Polish Prussians in the region.