Gamboa split the 2009 season between three affiliates, the Single-A Delmarva Shorebirds, the High-A Frederick Keys, and the Double-A Bowie Baysox, accumulating an excellent 11-0 record and 1.08 ERA with 75 strikeouts in 39 games between the three clubs.

Gamboa reached Triple-A for the first time in 2012 with the Norfolk Tides, also playing in Bowie and Frederick, accumulating a 10-5 record and 3.61 ERA with 86 strikeouts in 29 games.

[8] Gamboa was handed a 50-game suspension for testing positive for "exogenous testosterone," a performance-enhancing substance in violation of the Minor League Drug Prevention and Treatment Program on June 13, 2014.

Assigned uniform number 68,[11] he was optioned back to the Norfolk Tides without appearing in any Orioles games two days later on April 13, 2015 when David Lough was reinstated from the disabled list.

[13] Gamboa signed a minor league deal with the Tampa Bay Rays in January 2016.

[16] On February 14, 2017, the same day as being designated for assignment from the Rays, Gamboa was traded to the Texas Rangers for a player to be named later or cash considerations.

On June 30, 2017, Gamboa signed a minor league deal with the Los Angeles Dodgers.

[21] He split the season between the Double–A Bowie Baysox and Triple–A Norfolk Tides, accumulating a 2.88 ERA with 16 strikeouts and 2 saves across 25 innings pitched.