After a brief assignment in the Local Congregation of Project 4, Quezon City, he was appointed Assistant Dean of EVCO.

His administrative capability was further honed as a Coordinator of the Metro Manila Ecclesiastical Districts (at present, Metro Manila is divided into nine (9) districts) beginning in 1984:[1] Eduardo Manalo founded the Society of Communicators and Networkers (SCAN) for INC members with a common interest in radio communication to help and assists the community during emergencies.

He also began and maintained a popular Bulletin Board System (BBS) and further developed his programming skills.

[4] Over the months of July to August 1998, he conducted a pastoral visitation to Hawaii and the US in commemoration of the 30th year of the INC in the West.

Another major pastoral visitation took place over the months of April to May 2006, to the local congregations in Europe, Middle East, and Asia.

The property includes a school building which was formerly owned by Helen and Constantine Greek Orthodox Church.

[9] On March 14, 2014, after conducting a worship service in Tacloban, Leyte, INC Executive Minister Eduardo V. Manalo, led the groundbreaking ceremony of EVM Self-Sustainable Community Rehabilitation Project in Sitio New Era, a 3,000-hectare property of the church in Brgy.

The project which could cost more than one billion pesos includes at least 1,000 housing units for the survivors of Super Typhoon Haiyan.

Garments and dried fish factories, and eco-farming project are also included to provide livelihood to the community.

More than 150,000 hunger relief packages were also given which contained 3 kilos of rice, canned goods and instant noodles aside from the free medical and dental services conducted that day.

Manalo was appointed by President Rodrigo Duterte as Special Envoy for Overseas Filipino Concerns, succeeding Roy Cimatu who held the position.