General Pazuello acted in the coordination of the Army troops during the 2016 Summer Olympics in Rio de Janeiro,[3] and, since February 2018, coordinated Operation Reception, which takes care of Venezuelan refugees in Roraima,[4] besides previously serving as Secretary of Finances in the State Government of Roraima during the federal intervention,[5] where he announced his leaving in February 2019.

[6] On 8 January 2020, left the coordination of the operation to command the 12th Military Region in Manaus,[7] replacing Carlos Alberto Maciel Teixeira.

[8] He was nominated Executive Secretary of the Ministry of Health by former minister Nelson Teich to be the second in command, replacing João Gabbardo.

[9] In May 2020, a report by Agência Sportlight revealed that Eduardo Pazuello alleged "non-commercial use" in a contract of 13 years signed between Infraero and a company that earned R$ 5,000 (US$ 760.55) per parachuting student, accusing him of administrative dishonesty.

[12] On 19 May 2020, Pazuello allowed the use of hydroxychloroquine and chloroquine for treatment against COVID-19,[13] and, in June 2020, he was nominated Minister of Health and removed from his previous office as Executive Secretary.