As the originator of the profession, Angle founded three orthodontic schools between 1905 and 1928 in St. Louis, Missouri, New London, Connecticut and Pasadena, California.

During his childhood years he demonstrated early talent of working with tools and machinery including hay rake.

As soon as his health improved, he came back to Pennsylvania to eventually move to Montana to open a sheep-ranching business with his older brother Mahlon.

He eventually opened his school in his new Tudor revival home, designed by the same architect of 58 Bellevue Place, in Pasadena in 1917.

The fourth edition, The angle system of regulation and retention of teeth and treatment of fractures of maxillae, was published in 1895.

In November 1899, he taught a Postgraduate course on orthodontia in his office in St. Louis where his students urged him to create a school for teaching Orthodontics.

He coined the term malocclusion to refer to anomalies of tooth position and classified various abnormalities of the teeth and jaws, invented appliances for their treatment and devised several surgical techniques as well.

Concurrently, this comprehensive system provided clarity and simplicity to defining healthy dentition alignment with its categorization of major types of malocclusion.

The artist and dentist collaborated for many years and Wuerpel lectured frequently at Angle's request, in St. Louis as well as in Pasadena.

Having a full set of teeth on both arches was highly sought after in orthodontic treatment due to the need for exact relationships between them.

Concurrently, this comprehensive system provided clarity and simplicity to defining healthy dentition alignment with its categorization of major types of malocclusion.

Once a molar position is determined, a line of occlusion forms along its central fossa that smoothly meanders across both upper and lower teeth.