Sir Edward Chamberlain (or Chamberlayne) (1480 – 1543) of Shirburn Castle, Oxfordshire was an English soldier knight and Member of Parliament.
[1] He was born the eldest son of Richard Chamberlain of Coton, Northamptonshire and his wife Sybil Fowler and succeeded his father in 1497.
His mother took out a lease on the Shirburn estate from her brother in 1505, which passed to Edward on her death in 1525.
He then commanded a ship during naval hostilities early in 1513, joined the royal army in northern France in the summer, and was knighted at Tournai later that year.
He served at a royal banquet at Greenwich in July 1517 and in 1520 attended both Henry VIII's meeting with the King of France at the Field of Cloth of Gold and his subsequent meeting with the Charles V, Holy Roman Emperor at Gravelines.