Built in 1880, it was a longtime home of Edward Drinker Cope (1840–1897), a prolific geologist and paleontologist and noted herpetologist who was one of the leading natural scientists of the 19th century United States.

The front facades are clad with rectangular cut green stone laid in random courses.

Financial reverses due to a poor investment in 1886 forced him to rent 2100 out, and he occupied 2102 until his death in 1897.

The Pine Street home was filled with Cope's papers, bones, stuffed and mounted animals, and specimens preserved in alcohol that covered his desks and an improvised shelf in his bathroom.

[5] Cope was a prolific and talented scientist, distinguishing himself in the field of paleontology, where he was one of the leading figures in the infamous Bone Wars competition that characterized the scientific investigations of the American West in the 1870s.