At some point between 1631 and 1641, he became organist and master of the choristers of Christ Church Cathedral, Oxford.
He deputised for John Wilson as Heather Professor of Music, succeeding him in 1661; he also became an organist of the Chapel Royal soon afterwards.
At Oxford, he increased the university's collection of music by purchases and by receiving gifts.
[1] In 1661, after the restoration of the monarchy, Lowe wrote a collection of simple settings of music for church and cathedral services, for the use of choirs newly reestablished after the end of the Commonwealth.
He composed various pieces for Oxford occasions, including "Nunc est canendum" (possibly to mark the opening in 1669 of the Sheldonian Theatre), and for Christ Church; some vocal compositions and one work for keyboard also survive.