USS Hughes (DD-410) was a World War II-era Sims-class destroyer in the service of the United States Navy.

His commanding officer later wrote, "The action of Lieutenant Hughes in setting fire to the enemy's sunken ships in the face of a well armed superior, but demoralized force, was the one act of conspicuous gallantry which the battle that day afforded.

She screened the carrier in strikes on Jaluit, Makin, Mili, and Canton Islands, then supported the combined Lexington–Yorktown Task Force 17 (TF17), as it attacked Japanese bases at Lae and Salamaua on 10 March 1942.

When the carrier was torpedoed by a submarine on 6 June, Hughes helped damage the attacker with depth charges, and rescued the survivors when Yorktown sank the next day.

Hughes took part in the invasion of Hollandia, New Guinea on 23 April 1944, acting as a screen for the escort carrier group which provided air cover for the landings at Aitape and Tanahmerah Bay.

Hughes remained off New Guinea as a convoy escort and fire-support ship of the 7th Fleet until 25 September, when she departed for the invasion of the Philippines.

During this time, Hughes participated in the invasions of Biak, Noemfoor, Cape Sensapor, and Morotai, serving as flagship of Rear Admiral William M. Fechteler during the latter campaign.

Following the successful conclusion of this operation, Hughes screened Philippine bound convoys, making frequent trips to and from New Guinea until 6 December 1944, when she reembarked Admiral Struble and departed for the invasion of Ormoc Bay, Leyte.

After a long testing period, Hughes was declared combat ready and departed for Adak Island in the Aleutians on 4 June 1945.

Assigned to the Northern Pacific Force, she remained in the Aleutians until the end of the war, harassing enemy shipping and bombarding Japanese bases.

Following the test she was towed to sea and sunk off Kwajalein on 16 October 1948, and struck from the Naval Vessel Register on 26 November 1948.