Rear-Admiral Edward O'Bryen (sometimes O'Brien) (c.1753 – 18 December 1808) was a British Royal Navy officer prominent in the late eighteenth century, who is best known for his participation at the Nore Mutiny and the Battle of Camperdown, both in 1797 during the French Revolutionary Wars.

He was still in post in July 1796 when Man abandoned Gibraltar and returned to Britain without orders, inviting severe censure from the Admiralty, government and Admiral Sir John Jervis.

Nassau was a disaffected ship, its men had been unpaid for the previous 19 months service, and when the Nore Mutiny broke out in May 1797, O'Bryen's authority was challenged and resisted by his crew.

[1] In July, Onslow and O'Bryen moved to HMS Monarch and on 11 October 1797 served with Admiral Adam Duncan's fleet at the Battle of Camperdown.

O'Bryen was promoted to rear-admiral in 1805, but ill-health prevented any return to the sea and he died in December 1808, acknowledging an illegitimate son named James Cavendish in his will.