Edward Brewster Sheldon (February 4, 1886, in Chicago, Illinois – April 1, 1946, in New York City) was an American dramatist.

After becoming ill at age 29 with crippling rheumatoid arthritis, which eventually claimed his sight (around 1930), Sheldon became a source of emotional and creative support for his many friends, notably Minnie Maddern Fiske (he wrote Salvation Nell for her), Julia Marlowe, John Barrymore (his closest friend and confidante), Thornton Wilder, Alexander Woollcott, Anne Morrow Lindbergh, Ruth Gordon, Helen Hayes.

Actress and librettist Dorothy Donnelly formed a close friendship with Sheldon, and after he became bedridden often assisted with transcribing, editing, and supporting his work.

A 1936 lawsuit against Metro-Goldwyn-Mayer for copyright infringement claimed that the script MGM used for the 1932 motion picture Letty Lynton plagiarized material from the play Dishonored Lady by Sheldon and Margaret Ayer Barnes.

In this biography Barnes states that Sheldon was in love all his adult life with Doris Keane, the actress who starred in Romance in 1913.