The Edwin DeVries Vanderhoop Homestead, is an historic house at 35 South Road, Aquinnah, Massachusetts, United States.

The c. 1890s house is the first built by a member of the Vanderhoop family, which is prominent in the town politics of Aquinnah and in the tribal organization of the Wampanoag Tribe of Gay Head.

1816) was the first member of the Vanderhoop family to move to what is now Aquinnah, Massachusetts on the island of Martha's Vineyard, but was then a reservation of the Wampanoags of Gay Head.

In 1837, he married a Wampanoag woman and raised a large family, whose descendants continue to be prominent in the affairs of the town and tribe.

In 1869, the Commonwealth of Massachusetts began the process of incorporating the town of Gay Head (as Aquinnah was called before 1998) by dividing the tribal lands among its members.

The main body of the house consists of two large Cape style sections whose ridge lines run east–west, but at an offset from each other.