He signed with the Arizona Cardinals of the National Football League (NFL) as an undrafted free agent in 2015, and then spent two seasons with the Indianapolis Colts.

[1] Making the Georgia Southern Football Team as a tryout walk-on, Jackson saw action in 13 games as a freshman, and had 10 tackles.

Earning the starting middle linebacker spot his junior season, Jackson totaled a team-best 92 tackles, 2.0 sacks and a fumble recovery in 11 games.

A highlight game that year featured Jackson posting 10 tackles, including a team-leading eight solo stops in 26–20 upset win against the University of Florida.

Jackson was named the College Sports Madness Southern Conference Player of the Week for his performance against the Florida Gators.

[citation needed] In Jackson's senior year, he was voted team captain by his teammates, and recorded a career-high 100 tackles, which ranked in the top- 10 of the Sun Belt Conference.

[2][3] Jackson was nominated for the Burlsworth Trophy, which nationally honors former walk-on players who have made significant contributions to their school's team.

[14] On September 21, 2018, Manuel Orrego-Savala was sentenced to the maximum of 16 years in prison after pleading guilty on July 20, 2018 to two counts of operating a motor vehicle with a blood alcohol content of 0.15 or more, causing death.